CXZ automatic chromatography unit

System composition and characteristics

Automation Control System

Based on the advanced distributed control strategy of DCS, the chromatographic workstation realizes the control and data acquisition of pumps, valves and all kinds of on-line detectors, and can facilitate the parallel connection of multiple columns and parallel operation to ensure the stability and accuracy of the process.

Chinese medicine dedicated online testing system

Including the detection of the normal process parameters such as flow rate, pressure, temperature, PH value (optional), conductivity (optional) and the use of UV spectroscopy (optional), NIR spectroscopy (optional) Content of the real-time detection side.

Column structure

The column structure is well designed, reasonable aspect ratio, precise inlet and outlet fluid distribution device, equipped with automatic filling system and compressed air interface, to ensure that the pillared column packing effect and packing regeneration effect, to provide efficient protection for the separation.

Application of Chromatographic Separation Technology in Separation and Purification of Natural Products

In the separation and purification of traditional Chinese medicine applied more chromatographic separation techniques are adsorption chromatography and ion exchange chromatography. Adsorption chromatography including reverse phase chromatography (C18 reverse phase packing) and normal phase silica gel chromatography; ion exchange chromatography is mainly used for the separation and purification of sub-charged compounds. At present, chromatographic separation technology plays an increasingly important role in the purification of the active ingredients of traditional Chinese medicines such as flavonoids, alkaloids, glycosides, organic acids and polysaccharides.

The unit is specifically designed for the purification of industrial-scale target compounds in the pharmaceutical industry. The preparation of liquid chromatography column, with an extremely high sample loading capacity, provides a reliable guarantee for increasing the amount of purified product prepared at a lower cost.

Features

Widely used in protein, enzymes, monosaccharides, polysaccharides and plant extracts and other active ingredients and refining. Chromatographic separation is characterized by: mild operating conditions (room temperature, usually atmospheric pressure); the mixture can be obtained by a single pass at the same time more than pure components can be finely separated to obtain high purity products. The unit into the modern computer automation control technology, process parameters on-line detection technology, the traditional manual chromatography equipment to upgrade and improve the reliability of equipment, the device easy to layer folding process amplification to solve the problem of industrial production.

Natural product separation and purification applications

The development of small test technology, pilot study of amplification, phytochemical standards, the preparation of reference substance. Widely used in the separation of phenols, aldehydes, alkaloids, amino acids, steroids, mushrooms, flavonoids, quinones, organic acids, glycosides, sugars, nucleosides and other pure products. Such as: paclitaxel, tea polyphenols, ginkgo flavonoids, bamboo leaves flavonoids, vitamin E and so on.